Analysis of factors influencing serum lipids of patients with chronic hepatitis B infection / 第二军医大学学报

ABSTRACT

Objective: To evaluate the different factors on serum lipids in chronic hepatitis B patients by multiple linear regression analysis. Methods: The liver function parameters, the renal function parameters and the serum glucose of 323 cases with viral B hepatitis and 39 healthy persons (as control group) were measured by automatic biochemical analyzer, the load of hepatitis B virus were measured by quantitative PCR analyzer and the plasma prothrombin activity (PTA) were detected with automatic coagulometer. Results: The serum lipids level were decreased with the deterioration of liver function in chronic hepatitis B patients, and there are statistical significant differences between the groups. It can be found that the serum lipids level of chronic hepatitis B patients were mostly affected by the plasma prothrombin activity and liver function, but the parameters of age; gender; serum glucose; hepatitis B viral load; renal function have minor or no effect on the serum lipids level of chronic hepatitis B patients by the analysis of multiple linear regression. And it can also be observed that In the many indicators, CHOL, TG mainly affected by the PTA, and HDL, LDL mainly affected by the ALB. Conclusion: It can be found that the serum lipids in chronic hepatitis B patients are mostly affected by the liver function by multiple linear regression analysis. And It has an important clinical value in judgment of patient's condition and estimatement of patient's prognosis by detect lipid levels in chronic hepatitis B patients.