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Changes of peripheral pain threshold in transient receptor potential vanilloid 1 knockout female mice / 第二军医大学学报
Article in Zh | WPRIM | ID: wpr-839978
Responsible library: WPRO
ABSTRACT
To investigate the changes of peripheral pain threshold after knockout of transient receptor potential vanilloid l (TRPVl) gene. Methods Tail-Flick Analgesia Meterand von-Frey hair were used to determine the peripheral thermal and mechanical thresholds in TRPVl knockout and wild-type female mice, and the results of the two groups were compared. Results The Tail-Flick latency in TRPVl knockout mice was significantly prolonged after hot stimulation compared with that in the wild-type group([3.59±0.65] s vs [2.l9±0.24] s, P0.05). Conclusion It is suggested that TRPVl receptor mediate thermal stimuli response under physiological condition, and has no noticeable influence on mechanical stimuli response.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Academic Journal of Second Military Medical University Year: 2011 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Academic Journal of Second Military Medical University Year: 2011 Type: Article