Role of oligodendrocyte precursor cells in myelination and remyelination: Recent advance / 第二军医大学学报

ABSTRACT

Demyelination disables saltatory conduction and leads to neural dysfunction. Remyelination is mediated by oligodendrocyte precursor cells (OPCs), which are widely distributed in the central nervous system (CNS) of adults. A belter understanding of oligodendrocyte biology, mechanisms of myelination and maintenance of myelin sheaths, and the relationship of failed remyelination in the CNS with the number, migration, and myelinating ability of endogenous OPCs, will greatly improve the remyelination strategies in chronic inflammatory demyelinating diseases, including muitiple sclerosis.