Protective effects of Shuxuening injection on myocardial injury in rats with sepsis / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 175-178, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-840103
ABSTRACT
Objective:
To investigate whether Shuxuening injection has a protective effect on myocardial injury in rats with cecal ligation and puncture(CLP)- induced sepsis.Methods:
Thirty SD rats were randomly allocated to Sham group, CLP group and Shuxuening group (SXN group). In the Shuxuening group, Shuxuening injection was intraperitoneally injected at a dose of 1 mg(0.3 ml)/body weight 1 h before CLP challenge. The sham and CLP groups received an equal volume of saline injection (0.3 ml/kg) at the same time points. Six hours later, the blood samples were obtained from abdominal aorta to determine the contents of TnT, TNF-α, and IL-1β. Meanwhile, MDA contents and SOD activities in myocardial tissues were also tested and the pathologic changes of the myocardial tissue were observed by H-E staining.Results:
Compared with CLP group, the serum contents of TnT, TNF-α, and IL-1β and myocardial tissue MDA were decreased in Shuxuening group; and the myocardial tissue SOD activities were significantly increased in Shuxuening group (P<0.05 or 0.01). Microscope observation showed that the degrees of myocardial congestion, edema, and inflammatory cell infiltration were greatly improved in the Shuxuening group compared with in the CLP group.Conclusion:
Our results suggest that Shuxuening can protect against CLP-induced myocardial injury in rats, probably through scavenging free radical and inhibiting release of inflammatory mediators.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2011
Type:
Article
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