Effects of dexmedetomidine on blood glucose, β-endorphin, tumor necrosis factor-α and interleukin-6 in patients undergoing radical esophagectomy / 第二军医大学学报

ABSTRACT

Objective: To investigate the effects of dexmedetomidine on blood glucose, β-endorphin (β-EP), tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) levels in patients undergoing radical esophagectomy, and to discuss the possible mechanism. Methods: Forty patients with esophageal carcinoma undergoing radical esophagectomy were randomly assigned to 2 groups dexmedetomidine group and control group (n = 20 in each). Blood samples were taken immediately before induction of anesthesia (T0), immediately after tracheal extubation (T1), day 1 and day 2 after operation (T2, T3) for determining the levels of blood glucose, plasma β-EP and serum TNF-α and IL-6. Results: Compared with those at T0, MAP and HR at T1 were significantly elevated (P0.05), and the above parameters were significantly different between the two groups at corresponding time pionts (P< 0.05). Conclusion: Continued application of dexmedetomidine can effectively decrease the levels of blood glucose, plasma β-EP, serum TNF-α and IL-6 in patients undergoing radical esophagectomy, inhibiting the peri-operative stress response.