Screen of seasickness behavior indices of simulated seasickness in rats and observation of adaptability rules / 第二军医大学学报

ABSTRACT

Objective: To screen for seasickness behavior parameters in rats with simulated seasickness, so as to investigate the rule of seasickness adaptation in rats. Methods: SD rats were stimulated daily by Crampton model. Urine volume (UV) and amount of fecal particle (FP) were observed during stimulation, and the spontaneous activity (SA) was also determined immediately after stimulation. Interventional experiments were performed using anti-motion sickness drugs to examine the specificity of the indices. Results: On the first day of stimulation, the FP of stimulating group increased significantly compared with the normal control group (P<0.05), while SA decreased significantly (P<0.01). FP and SA of stimulating group gradually recovered with the increase of stimulation period; there was a significant correlation between FP, SA with stimulation times (P<0.01). FP and SA recovered to the normal levels on the 9th, 7th day, respectively. The experimental group received gastric perfusion of scopolamine (0.5, 1 mg/kg) and was then subjected to rotation stimulation. The indices had no significant difference between the experimental group and the normal control group. Conclusion: It is indicated that FP during stimulation and SA after stimulation can be used for effective judgment of seasickness in rats. The rats become adapted to seasickness after 9 days' continuous stimulation.