Triggering receptor expressed on myeloid cells-1 and inflammation- associated diseases: Recent progress / 第二军医大学学报

ABSTRACT

Triggering receptor expressed on myeloid cells-1 (TREM)-1, a recently identified molecule, is involved in monocytic activation and inflammatory responses. TREM-1 is a member of natural killer cell receptor family and is expressed on neutrophils, mature monocytes and macrophages, and it can enhance the inflammatory responses mediated by Toll-like receptor-2 and -4, showing a role of inflammation promotion. Reportedly sTREM-1 was detectable in the body fluids in the presence of bacterial or fungal infection; therefore it might be used as a marker for inflammation. In addition, recombinant sTREM-1 may also be a new method for anti-inflammatory therapy. Recently, it has been found that TREM-1 not only promoted the acute inflammatory responses, but also participated in the development of chronic inflammation. This review summarizes the role of TREM-1 in the inflammation-associated dieases.