Clinical and prognostic analysis of bone metastases of non-small-cell lung cancer / 第二军医大学学报

ABSTRACT

Objective: To study the clinical features and prognostic factors of bone metastases of non-small-cell lung cancer. Methods: The clinical data of 174 patients with bone metastases of non-small-cell lung cancer, who were treated in our hospital during April 1999 to June 2006, were retrospectively analyzed. Kaplan-Meier analysis was used to estimate the 1- and 2-year survival rates of patients. Log-rank test was used to screen the factors influencing the survival of patients and Cox regression was used to further confirm the independent factors. Results, The predilection sites of bone metastases of non-small-cell lung cancer were chest (38.1%), spine (32.8%), pelvis (16.3%), extremities (8.7%), and skull (4.1%), with the ribs (30.7%), lumber vertebrae (17.3%), and thoracic vertebra (13.1%) ranking the top three. The median survival time of the 174 patients was 10.73 months; Kaplan-Meier analysis showed that the 1- and 2-year survival rates were 47.1% and 17.8%, respectively. It was also showed that the PS Score, bone pain, asymptomatic bone metastases, solitary bone metastasis, serum AKP, LDH, and CEA were associated with the prognosis of patients (P<0.05). Multivariate analysis showed that PS score, solitary bone metastasis and single bone metastasis were the independent factors of prognosis. Conclusion: The predilection sites of bone metastasis of non-small-cell lung cancer include chest part (ribs), spine (lumber/thoracic vertebrae), pelvis (ilium), etc. PS score, asymptomatic bone metastases, and solitary bone metastasis have great influence on the prognoses of patients.