Efficacy and adverse effects of gemcitabine plus cisplatin regimen and fluorouracil plus cisplatin regimen in treatment of advanced nasopharyngeal carcinoma: A meta-analysis / 第二军医大学学报

ABSTRACT

Objective: To compare the efficacy and adverse reactions between gemcitabine + cisplatin regimen and fluorouracil + cisplatin regimen in the treatment of advanced nasopharyngeal carcinoma (NPC). Methods: The Cochrane Library,. MEDLINE, EMbase, CBM and CNKI were searched for related articles published before 2009. Manual searching and additional searching were also performed. The quality of each included studies was evaluated by 2 independent oncologists and analyses of homogeneous property of the studies were done by RevMan 5.0 software. Results: Four studies were enrolled in our study, including 283 patients with NPC. Meta-analyses showed that the 1-year- and 3-year-survival rates of gemcitabine + cisplatin regimen were similar to those of fluorouracil+cisplatin regimen (Z = 0.89, P = 0.37), (Z = 0.70, P = 0.09), but gemcitabine+ cisplatin regimen had significantly higher remission rate (Z = 2. 34, P = 0.02) and slighter myelosuppression and gastrointestinal reactions (Z = 2.47, P = 0.01), (Z = 3. 20, P = 0.001), (Z = 2.19, P = 0.03). Conclusion: Gemcitabine +cisplatin regimen has equivalent efficacy and slighter adverse effects compared with fluorouracil + cisplatin regimen in treatment of advanced nasopharyngeal carcinoma.