Anti-aging activity of Mytilus coruscus polysaccharide in aged SD rats / 第二军医大学学报

ABSTRACT

Objective: To investigate the anti-aging activity of Mytilus coruscus polysaccharide (MP) in aged rats. Methods: We established a 24-month natural aging rat model. Twenty model rats were divided into 4 groups, namely, the aging model group, Mytilus coruscus powder group (MCP 1 g/kg), high dose MP group (MP 400 mg/kg), and low dose MP group (MP 200 mg/kg). Five three-month-old rats served as young control. The Mytilus coruscus power solutions and MP solutions were given intragastrically on a daily basis for 90 days. The organ indices of the heart, liver, kidney, and spleen of rats were observed; the pathology of the hearts and livers was also observed. The levels of superoxidedismutase (SOD), glutatio-neperoxidase (GSH-Px), and malonaldehyde(MDA) in the serum and liver were determined; and the main serum parameters were also determined. Results: Compared with the aging model group, the heart and liver pathology had no obvious aging changes in the high dose MP group. The serum and liver SOD, GSH-Px levels were significantly higher in the high dose MP group than those in the aging model group (P<0.01); the MDA level was significantly lower than those in the aging model group (P<0.01). Conclusion: The Mytilus coruscus polysaccharide possess anti-aging activity, and the anitoxidative effect might be one of the mechanism for the anti-aging effect.