Synthesis of pyridazinone derivatives and study of their antiplatelet aggregation activity / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 821-824, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-840539
ABSTRACT
Objective:
To study the influence of different amino group introductions on the antiplatelet aggregation activities of pyridazinone derivatives.Methods:
The target compounds were designed and synthesized by inletting different substitution amino groups using acetyl fragment as the connecting segment. Born method was used for preliminary pharmacological test in vitro.Results:
Ten target compounds were designed and synthesized; 8 of them were reported firstly and all of them were confirmed by 1HNMR spectra. The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregation activity. The antiaggregation activities of compounds (6f), (6g), (6h) and (6j) were stong; compounds (6g) and (6j) showed a 5-time higher activity than 6-[4-(pyridin-4-yl-amino) phenyl]-4, 5-dihydro-3 (2H)-pyridazinone (MCI-154).Conclusion:
Inletting different substitution amino groups can enhance the antiplatelet aggregation activity of the compounds.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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