Expression of Let-7c in invasive ductal carcinoma of breast cancer and its clinical significance / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 400-403, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-840610
ABSTRACT
Objective:
To investigate the expression of Let-7c in patients with invasive ductal carcinoma of the breast cancer and its correlation with the clinicopathologic features of the patients.Methods:
The expression of Let-7c was examined in 40 tissues of invasive ductal carcinoma of the breast cancer and their matched non-tumor adjacent tissue specimens by stem-loop real-time RT-PCR. The correlation of the expression with the clinicopathological features of breast cancer, such as the clinical staging, lymphatic metastasis, and proliferation index, was analyzed.Results:
The stem-loop realtime RT-PCR was sensitive and specific in detecting Let-7c expression. Expression of Let-7c in breast cancer tissues was significantly lower than that in the adjacent normal tissues (P10%) (P=0.030) and the status of Estrogen/Progesterone receptor (P=0.040/0.034) in breast cancer patients. There was no significant association of Let-7c expression with menopause condition, breast cancer TNM clinical stage, or lymphatic metastasis(P>0.05).Conclusion:
Our results suggest Let-7c may play an important role in the development of breast cancer and the level of Let-7c expression may be a potential parameter in forecasting the progression and prognosis of breast cancer patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS