Gender difference in activation of platelets in septic rats / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 249-251, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-840625
ABSTRACT
Objective:
To investigate the influence of gender difference on the activation of platelets in septic rats.Methods:
Totally 20 female and 20 male SD rats were randomly divided into four groups male sham-operated group, female sham-operated group, female septic group, and male septic group, with each group containing 10 rats. Sepsis model in the last two groups was produced by cecal ligation and puncture (CLP); rats in the sham-operated group received no CLP. The rats were sacrificed 24 hours after surgery; the blood samples were collected for blood routine test; and the serum β-TG levels were detected by ELISA assay. Serum estrogen (E2) levels were detected by radioimmunoassay.Results:
The blood platelet counts were decreased in both septic rats of both genders; the count in female rats was significantly higher than in the male rats (P< 0.01). The serum β-TG levels were increased in septic rats of both genders; the level in the female rats was significantly lower than that in the male rats (P<0.01). The blood platelets count in female or male septic rats was significantly positive correlation with the level of serum estrogen and the β-TG expression in female or male septic rats was significantly negative correlation with the level of serum estrogen(P<0.05).Conclusion:
There is a gender difference in the activation of platelets in septic rats, and the endogenous estrogen may have protective effect on the platelets of female septic rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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