Correlation analysis between HBV Pre-S1 antigen with HBeAg and HBV DNA / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 1306-1308, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-840983
ABSTRACT
Objective:
To study the correlation between HBV Pre-S1 antigen, HBeAg levels and HBV DNA copies, so as to assess the clinical value of Pre-S1 in detection of HBV replication.Methods:
A total of 363 HBsAg-positive samples were collected. The levels of Pre-S1 antigen, HBeAg and HBV DNA copies were determined by ELISA, time-resolved immuno-fluorescent method and real-time fluorescent quantitative PCR(FQ-PCR),respectively. The correlation between the determination results was analyzed.Results:
Pre-S1 antigen level was correlated with the level of HBeAg (χ2 = 94.4,P<0.01), with the coefficient being 0.45; Pre-S1 antigen level was also correlated with HBV DNA(χ2 = 198.58, P<0.01), with the coefficient being 0.59. The positive rate of Pre-S1 increased with HBV DNA copies. When logarithm of HBV DNA copies was more than 3, the sensitivity, specificity, accuracy, positive predictive value(PPV), positive likelihood ratio(PLR) and odds ratio(OR) of Pre-S1 were 84.5%,91.2%,87.0%,94.1%,9.6,and 56.8 respective; the numbers of HBeAg were 50.4%,94.9%,67.2%,94.2%, 9.8 and 18.9, respectively.Conclusion:
Pre-S1 antigen is correlated with HBV DNA and is more sensitive and accurate than HBeAg in reflecting HBV replication. The above 3 parameters can complement each other and the combination of them is more accurate in clinical diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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