Effect of arterial baroreflex on survival rate of rats with cecal ligation and puncture-induced sepsis / 第二军医大学学报

ABSTRACT

Objective: To investigate the effect of arterial baroreflex (ABR) on survival rate of rats with cecal ligation and puncture (CLP)-induced sepsis. Methods: Male Sprague -Dawley rats were divided into 2 groups sham-operated rats (n=22) and sinoaortic denervated (SAD) rats (n=22). Four weeks after SAD rats were subjected to CLP-induced sepsis, the blood pressure and heart period (HP) were monitored for 12 hours in conscious state and the survival of rats was observed. Results: Both the diastolic and systolic blood pressue gradually decreased after CLP; the HP shortened first and then drastically prolonged until the death of rats. At 12 h after CLP the survival rate of SAD rats was lower than that of the sham-operated rats (59% vs 86%). Significant differences were found between the Kaplan-Meier survival curves of the rats in 2 groups (P<0.05). Conclusion: ABR plays an important role in CLP-induced lethal sepsis model.