Modification and application of the third-generation adenovirus vectors / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 722-725, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-841092
ABSTRACT
Adenovirus as gene transfer vector is characterized by high transfection efficiency, high titer, good stability in target cells and low pathogenicity, and has been widely used in gene therapy. Compared to first- and second-generation adenovirus vectors, the third-generation adenovirus vectors have unique advantages for gene therapy because of their low immunogenicity and high capacity. However, the clinical application of the third-generation adenovirus vectors is hampered by the existance of helper contamination and difficulties in their large-scale production.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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