Expression of Bcl-2 and Bax in renal tissues of patients with hepatitis B virus-associated glomerulonephritis / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 492-494, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-841128
ABSTRACT
Objective:
To investigate the expression of Bcl-2 and Bax in renal tissues of patients with hepatitis B virus-associated glomerulonephritis (HBV-GN).Methods:
Twenty HBV-GN specimens with complete nephrology data and 10 normal renal specimens were randomly chosen for the present study. Cell apoptosis was detected by means of terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling (TUNEL) and the apoptotic index was calculated; immunohistochemistry was used to detect the protein expression of Bax and Bcl-2.Results:
The apoptotic index in HBV-GN group was obviously higher than that of the control group; the apoptotic cells were mainly distributed in the proximal and distal renal tubules and the collecting duct epithelial cells, seldom seen in the glomerular cells. The expression of Bcl-2 in HBV-GN patients was predominately present in the renal tubular epithelia cells (positive in the plasma, membrane and nuclear); the expression of Bax was found in both glomerular cells and renal tubular cells, mainly in tubular epithelial cells, seldom seen in Bowman's capsule or glomerular mesangial region.Conclusion:
Apoptosis in the kidney of HBV-GN patients mainly occurs in the renal tubular epithelial cells; expression of Bax and Bcl-2 is mainly in the renal tubular epithelial cells, suggesting that the injury of tubular interstitial damage may be one of the important factors for the development of HBV-GN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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