Effect of transdermal penetration enhancers on permeation ability of indomethacin and salbutamol / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 421-424, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-841159
ABSTRACT
Objective:
To study the effect of different transdermal penetration enhancers on the skin permeation ability of indomethacin and salbutamol in vitro.Methods:
Valia-Chien diffusion cell was adopted as the apparatus for in vitro skin permeation test. Excised SD-rat abdomen skin was pretreated with penetration enhancers including Azone, Propylene glycol, N-methylpyrrolidone, oleic acid, peppermint oil, and a combination of Azone and Propylene glycol. A UV method was established to determine the contents of indomethacin and salbutamol in receiver diffusion cells.Results:
Compared with blank control group, all the enhancers showed significant enhancement effect on the permeability of indomethacin and salbutamol except for propylene glycol (P < 0.01). Azone combined with propylene glycol showed the greatest ability to enhance the flux of indomethacin(125.91 μg · cm-2 · h-1) and salbutamol(155.94 μg · cm-2 · h-1).Conclusion:
Azone combined with Propylene glycol, Azone, N-methylpyrrolidone, Oleic acid, and Peppermint oil can be used as penetration enhancers in the transdermal preparation of compound indomethacin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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