A modified template matching algorithm for chromatographic fingerprint of S. miltiorrhiza Bge, a traditional Chinese herb / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 183-187, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-841203
ABSTRACT
Objective:
To introduce a new template peak matching algorithm for calculating the similarity of chromatographic fingerprint of traditional Chinese herbs.Methods:
Tanshinone II A in S. miltiorrhiza Bge of different batches were determined by HPLC and the chromatograms of them were obtained. We designated a new peak matching algorithm based on the previous algorithms, which employed a certain real chromatographic fingerprint as their template. In the new algorithm, we arranged the retention times of chromatographic peaks of all chromatograms into an ascending order, forming a template. The sorting procedure complied with the following 2 rules. First, the same peak matches the nearest corresponding peak. Second, one peak does not appear twice in the same chromatogram.Results:
The new algorithm avoided the shortcomings of previous algorithm, such as mismatching and missed matching, and obtained a satisfactory outcome.Conclusion:
Our new algorithm provides a basis for improving the reliability of retention time-based peak matching algorithm.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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