Synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl ester / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 101-102, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-841235
ABSTRACT
Objective:
To search for a new method for synthesis of 9 fluorenylmethoxycarbonyl amino acid tert-butyl ester.Methods:
Glycine, L-Proline, and L-Phenylanaline were separately allowed to react with 9-fluorenylnmthylchloroformate to obtain the corresponding 9-fluorenylmethoxycarbonyl amino acids. With 4-(dimethylamine) pyridine (DMAP) used as catalyst, the 9-fluorenylmethoxycarbonyl amino acids were allowed to react with Tert butyl dicarbonate for the corresponding 9-fluorenylmethoxycarbonyl amino acid tert-butyl esters.Results:
Three 9-fluorenylmethoxycarbonyI amino acid tert-butyl esters were successfully synthesized by this method and their structures were confirmed by 1 H NMR.Conclusion:
Ours is a simple method with mild condition and high yielding rate for synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl esters.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article
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