Amiodarone in prevention of atrial fibrillation after coronary artery bypass grafting / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 973-976, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-841326
ABSTRACT
Objective:
To evaluate the role of amiodarone in preventing atrial fibrillation after coronary artery bypass grafting (CABG).Methods:
Totally 184 patients receiving CABG under cardiopulmonary bypass (CPB) were randomly divided into amiodarone group (n=94) and placebo group (n=90), and patients in each group were further divided into ≥ 60 years and < 60 years subgroups. Patients in amiodarone group received routine drugs + amiodarone and those in placebo group received routine drugs + placebo.Results:
The overall incidence of postoperative AF (paroxysmal and persistent) was significantly higher in the placebo group compared with the amiodarone group (32. 2% vs 6. 4%, P<0. 01, OR=7.0). The incidences of postoperative AF were similar in patients aged <60 years between the placebo group and the amiodarone group, but were significantly different in patients aged ≥ 60 (P<0.05 or P<0.01). The postoperative AF incidence was significantly different between 2 age subgroups (P<0.05 or P<0.01) in the placebo group, but not in amiodarone group.Conclusion:
Amiodarone can effectively prevent post-operative AF, especially for patients aged ≥ 60 years. Amiodarone should be recommended to patients receiving CABG who aged ≥ 60 years.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2006
Type:
Article
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