Mitochondrial nitric oxide synthase: Biological function / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 656-659, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-841404
ABSTRACT
Increasing evidences have shown the existance of a mitochondrial nitric oxide synthase (mtNOS), which binds to the matrix face of the mitochondrial inner membrane and produces nitric oxide (NO) through a Ca2+ sensitive pathway. Under physiological condition, the NO catalyzed by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via reversible competition with cytochrome C oxidase. The reaction of NO with superoxide anion, which was produced by mitochondrial respiratory chain, yields peroxynitrite. Peroxynitrite irreversibly modifies susceptible targets in mitochondria and induces oxidative and/or nitrative stress. In addition, NO has also been implicated in the programmed cell death. This article reviews the current understanding of mtNOS's role in the regulation of mitochondrial functions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2006
Type:
Article
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