Correlation of nuclear DNA contents and p53 protein expression with CT image and prognosis of patients with epithelial ovarian tumors / 第二军医大学学报

ABSTRACT

Objective: To observe the nuclear DNA contents and expression of p53 protein in epithelial ovarian tumors (EOT) and to explore their correlation with CT images and prognosis in EOT patients. Methods: The nuclear DNA contents, expression of p53 protein and CT findings of 88 EOT patients were analyzed. Twenty-six EOT patients were followed up and were divided into AT group (ancuploid, n=19) and DT group (diploid, n=7) according to DNA ploid, and into p53 protein (+) group (n=15) and p53 protein (-) group (n=11) according to expression of p53 protein. The correlation of nuclear DNA content and p53 protein expression with CT findings and prognosis of EOT patients was analyzed. Results: The DNA index, patient number with AT and protein p53 (+) rate were significantly different between patients with their cystic wall thickness ≥ 3 mm and <3 mm, patients with and without cystic wall nodus, and patients with poorly-defined tumor boundary and well-defined tumor boundary in 88 patients with EOT( P<0. 01). The "enhanced degree of tumor parenchyma" in AT group was obviously higher than that in DT group(P<0. 01) , and was similar between protein p53 (+) group and (-) group. The survival periods of patients in DT group and protein p53 (-) group were longer than those in AT group and protein p53 (+) group (P<0.05, P<0.01). The survival periods of 12 patients in AT group with p53 protein (+) expression were all less than 48 months. Conclusion: Nuclear DNA and p53 protein are correlated with CT findings in EOT patients; the prognosis of ovarian carcinoma with aneuploidy and/or p53 protein (+) expression is poor.