Expressions of Foxp3+ regulatory T cells and myeloid dentritic cells in human colorectal cancer and tumor draining lymph node tissues and their significances / 吉林大学学报(医学版)

ABSTRACT

Objective: To explore the expressions of Foxp3 ' Tregs and CDllc mDCs in the colorectal cancer (CRC) tissue and their infiltrations in the tumor draining lymph node (TDLN) tissue, and to explore the clinical significances. Methods: Fifty-two samples of surgical resection of the CRC patients were collected The expressions of Foxp3 + Tregs and CDllc mDCs in the specimens of the CRC patients and TDLN tissue were detected by immunohistochemistry, and the relationship between the expression frequencies of Foxp3 + Tregs and CD11c+ mDCs and the clinicopathological characteristics of the patients were discussed Results: The positive expression frequency of Foxp3 + Tregs in cancer tissue of the CRC patients was higher than that in adjacent normal mucosa tissue (P0. 05). Conclusion: The occurrence and development of CRC are related to the changes of Foxp3 Tregs and CDllc mDCs expression frequencies in the local microenvironment of cancer tissue. Foxp3+ Tregs and CD11c+ mDCs play a role in inhibiting the cellular immunity in tumor microenvironment.