Associations between human plasma anti-gliadin antibodies and occurrence of schizophrenia in patients with different ages / 吉林大学学报(医学版)

ABSTRACT

Objective; To investigate the associations between the levels of human plasma anti-gliadin antibodies and occurrence of schizophrenia in the patients with different ages in Chinese Han population, and to clarify the effects of human plasma anti-gliadin antibodies in the occurrence of schizophrenia. Methods; The plasma samples were collected from 313 schizophrenia patients (schizophrenia group) and 408 healthy controls (healthy control group) in Chinese Han population. The levels of human anti-gliadin IgA and IgG antibodies of the subjects in various groups were detected by enzyme-linked immnosorbent assay (ELISA) method. The levels of human plasma anti-gliadin IgA and IgG antibodies in the subjects in schizophrenia group and healthy control group were analyzed by Pearson's correlation analysis and compared by Mann-Whitney U test; receiver operating characteristic (ROC) curve analysis was performed. Results; The level of plasma anti-gliadin IgA antibody showed a significantly positive correlation with the age and age ranges of the subjects (r= 0. 177, P0. 05). The ROC curve analysis results showed that the area under ROC curve (AUC) of anti-gliadin IgA and IgG antibodies were 0.573 (SE = 0. 022, 95% Cl 0.53-0.62) and 0. 520 (SE=0. 022, 95%CI; 0. 48-0. 56). The sensitivities of anti-gliadin IgA and IgG antibodies were 13. 7% and 12. 8% when the specificity was 92. 2%. Conclusion; The increasing of plasma anti-gliadin antibodies level is associated with the occurrence of schizophrenia in the patients with different age ranges in Chinese Han population, and the human plasma anti-gliadin antibodies maybe play an important role in the young schizophrenia patients.