Clinical effect of dexmedetomidine combined with non-invasive positive pressure ventilation in treatment of patients with AECOPD complicated with pulmonary encephalopathy and evaluation on its safety / 吉林大学学报(医学版)

ABSTRACT

Objective: To observe the clinical application of dexmedetomidine (Dex) combined with non-invasive positive pressure ventilation (NIPPV) in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with pulmonary encephalopathy, and to clarify its effectiveness Methods: A total of 80 patients with AECOPD and pulmonary encephalopathy were collected and divided into control group and Dex group according to the random digit table (n=40). The patients in control group were treated with conventional therapy, including antibiotics, phlegm, spasmolysis and NIPPV and so on. The patients in Dex group were treated with Dex based on conventional therapy. The heart rate (HR), blood pressure, arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbondioxide, the rate of endotracheal intubation, the effective rate of NIPPV and the compliance of NIPPV of the patients in two groups were analyzed before and after treatment. The expectoration capacity, delirium and anxiety of the patients in two groups were evaluated. Results: After conventional treatment, the HR, blood pressure and PaCO2 in two groups were lower than before treatment, and the PaO2 was higher than before treatment; the degrees of changes of the above indicators in Dex group were more obvious, the differences were statistically significant (P0. 05). The incidene rate of delirium and anxiety score of the patients in Dex group were lower than those in control group (P<0. 05). Conclusion: Dex combined with NIPPV is a safe and effective method in the treatment of the patients with AECOPD and pulmonary encephalopathy without obvious adverse effects.