Analysis on correlations between ultrasound features and positive expressions of CerbB-2 and Ki-67 in patients with breast cancer / 吉林大学学报(医学版)

ABSTRACT

Objective; To explore the correlations between the ultrasound features and the expressions of the molecular biological indicator human epidermal growth factor receptor 2 (CerbB-2) and Ki-67 in the patients with breast cancer. Methods; The ultrasonographic characteristics and paraffin section materials of 107 patients with breast cancer confirmed by pathology were collected. The correlations between the ultrasonographic characteristics and the expressions of CerbB-2 and Ki-67 were analyzed. Results; The positive expression rates of CerbB-2 and Ki-67 in breast cancer tissue were 73.83% (79/107) and 81.21% (87/107), respectively; the expressions of CerbB-2 and Ki-67 were positively correlated (r= 0. 264, P=0. 001). There were obvious correlations between the edge, size, shape, orientation, hyper-echoic halo, rear echo attenuation, micro calcification, flow signal 2-3 grade of breast cancer and the expression of CerbB-2 (P1, hyper-echoic halo, rear echo attenuation, micro calcification, flow signal 2-3 grade of breast cancer and the expression of Ki-67 (P 1 (P= 0.002) were the independent prognostic factors of breast cancer. Conclusion: There are significant correlations between some ultrasound features of breast cancer and the positive expressions of CerbB-2 and Ki-67 in the breast cancer tissue.