Detection of levels of serum visfatin and PGE2 in patients with periodontitis and their relationships with activity of periodontitis / 吉林大学学报(医学版)

ABSTRACT

Objective: To detect the levels of visfatin, prostaglandin E2 (PGE2) and interleukin-lβ (IL-1β) in serum of the chronic periodontitis patients, and to investigate the role of the above three factors in the pathogenesis of chronic periodontitis and their clinical significances in the assessment of activity of chronic periodontitis. Methods: A total of 79 cases of chronic periodontitis patients (including active and resting stages) were selected. The chronic periodontitis patients were divided into active stage of chronic periodontitis group (n=33) and resting stage of chronic periodontitis group (n=46) according to the diagnostic criteria for chronic periodontitis activity. A total of 25 cases of healthy volunteers were also selected as healthy control group. The serum of all cases were collected, then the serum levels of visfatin, PGE2 and IL-1β of the subjects in various groups were detected by ELISA method. The relationships between the serum levels of visfatin, PGE2 and IL-lfi were analyzed with Spearman and partial correlation analysis. Results: The levels of serum visfatin, PGE2 and IL-lfi of the patients in chronic periodontitis group were significantly higher than those in healthy control group (Pserum visfatin, PGE2 and IL.-1 (3 of the patients in active stage of chronic periodontitis group were significantly higher than those in resting stage of chronic periodontitis group (P< 0. 05). The correlative analysis results demonstrated that the serum IL-lfi level had positive relationships with the serum levels of visfatin and PGE2 of the patients in chronic periodontitis group (r=0. 68, Pserum visfatin level had positive relationships with the serum PGE2 level of the patients in chronic periodontitis group (r=0.63, Pserum visfatin level was, the higher the serum PGE2 level was. The serum visfatin level had significantly positive relationship with the serum PGE2 level of the patients in active stage of chronic periodontitis group (r=0. 78, Pserum levels of visfatin and PGE2 of the patients in resting stage of chronic periodontitis group had positive correlation at a low level (r=0. 45, P<0. 05).

Conclusion:

Visfatin and PGE2 may be involved in the pathogenesis of chronic periodontitis. The increasing of serum visfatin and PGE2 levels may predict the active stage of chronic periodontitis.