Association between genetic variations in 9p21 region and coronary heart disease in Chinese Han population / 吉林大学学报(医学版)

ABSTRACT

Objective: To analyze the association of the genetic variations of rs2383206 and rs2383207 in 9p21 region with the coronary heart disease (CHD) in the Chinese Han population, and to explore whether chromosome 9p21 is a susceptibility region for CHD. Methods: Case-control study was conducted. A total of 580 CHD patients were selected as case group, and 539 cases of non-cardiovascular disease patients or normal people with matched age and sex were selected as control group. The rs2383206 and rs2383207 loci of the subjects were genotyped with Sequenom Mass ARRAY time of flight mass spectrometer (TOF). Results: The smoking, waist-to-hip ratio (WHR), hypertension, diabetes mellitus, systolic blood pressure (SBP), diastolic blood pressure (DBP) and total cholesterol (TC of the subjects in two groups were statistically different (P0. 05), while the genotypic distribution of rs2383207 was statistically different (X2 =8. 936, P<0. 05); the distribution frequency of AA genotype in case group (8. 3%) was significantly lower than that in control group (13.6%) (P<0. 05). Conclusion: Smoking, WHR, hypertension, diabetes mellitus, SBP, DBP and TC may be the risk factors for CHD; the AA genotype of 9p21 rs2383207 loci may be the protective genotype of CHD.