Positive effects of low dose IMPX977 on Rett syndrome related MeCP2 targeted-genes / 中草药·英文版
Chinese Herbal Medicines
;
(4): 39-44, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-842094
ABSTRACT
Objective:
To investigate the effect of IMPX977 on MeCP2 targeted-genes and the feasibility of IMPX977 acting as a therapeutic candidate drug for Rett syndrome by genomewide transcription profiling.Methods:
Rats’ cortex of control group, IMPX977-treated low-dose group (10 mg/kg), and IMPX977-treated high-dose group (30 mg/kg) were collected and RNA was extracted from the tissues. Then, RNA was subjected to RNA-sequencing. Gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) were used in functional enrichment analysis of differentially expressed genes.Results:
Six MeCP2 targeted-genes were identified in the low/control categories, but not in the high/control categories.Conclusion:
Low-dose treatment of IMPX977 (10 mg/kg) showed a positive effect on MeCP2 targeted-genes and it may serve as a drug candidate for Rett syndrome therapy with proper dosage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Herbal Medicines
Year:
2019
Type:
Article
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