Typha angustifolia extract reduces diet-induced hyperlipidemia in rats / 中草药·英文版
Chinese Herbal Medicines
;
(4): 98-102, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-842100
ABSTRACT
Objective:
To observe the lipid-lowering effect of Typha angustifolia extract (TAE) in Sprague Dawley rats.Methods:
The rats were randomly divided into six groups, including the hypercholesterolemic diet (HYD) group. Ad libitum food was given to the animals for 60 d to establish dyslipidemia models. The rats were received an ig administration of 1 mL medicine daily. After 120 d the animals were sacrificed by cervical dislocation; Blood was collected to measure total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), nitric oxide (NO), and endothelin (ET) plasma concentration; Livers were collected to measure ApoE mRNA and protein expression; Morphologic changes of aorta ventralis tissue were also observed.Results:
Compared with HYD group, TAE had the ability of reducing TC, TG, LDL-C, NO, and ET (P < 0.01), thereby increasing ApoE mRNA and protein expression of the liver (P < 0.01).Conclusion:
These results suggested that TAE was capable of effectively decreasing the circulating lipids levels and enhancing the protective effects of artery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Herbal Medicines
Year:
2019
Type:
Article
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