α-Glucosidase inhibitors and antioxidants from root bark of Morus alba / 中草药·英文版
Chinese Herbal Medicines
;
(4): 331-335, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-842123
ABSTRACT
Objective:
To study the chemical constituents from root bark of Morus alba and their α-glucosidase inhibition and DPPH radical scavenging activities.Methods:
The chemical constituents were isolated and purified by repeated column chromatographies on silica gel, Sephadex LH-20, and preparative HPLC. Their structures were elucidated by 1D and 2D NMR spectra and HR-ESI-MS.Results:
Thirteen compounds 1–13 were isolated and identified. The bioactive assays revealed that compounds 1, 3 and 8 displayed strong α-glucosidase inhibitory activity with IC50 values of (147.1 ± 1.1), (314.1 ± 0.8), and (207.6 ± 0.1) µmol/L, respectively, which were stronger than the positive control of acarbose (418.6 ± 0.1 µmol/L). Compounds 10 and 11 displayed potent DPPH scavenging activity with EC50 values of (2.9 ± 0.1) and (5.0 ± 0.1) µmol/L [EC50 of positive control Vitamin C was (54.8 ± 0.1) µmol/L], respectively.Conclusion:
To the best of our knowledge, this is the first report about the compounds 1, 3, and 8 of M. alba with α-glucosidase inhibitory effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Herbal Medicines
Year:
2018
Type:
Article
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