Bioactive xanthones from whole plants of Gentianella acuta / 中草药·英文版

ABSTRACT

Objective: To study the constituents from the whole plants of Gentianella acuta and their biological activities. Methods: The compounds were isolated by multiple chromatographic methods and the structures of mentioned isolates were determined by routine NMR experiments and chemical methods. Results: A phytochemical investigation to obtain intestine motility inhibitor resulted in the isolation of one new xanthone glycoside, gentixanthonoside A (1), along with nine tetrahydroxanthones, 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (3), amarellin E (4), amarellin F (5), swertiachoside B (6), amarellin D (7), amarellin C (8), amarellin A (9), and amarellin B (10) from the whole plants of G. acuta. Conclusion: Compounds 2–10 showed significant reduce effects on contraction tension at 40 µM.