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In Silico Molecular Docking Study of Repensine and Bentysrepinine against HBV DNA Polymerase / 中草药·英文版
Chinese Herbal Medicines ; (4): 39-44, 2015.
Article in Chinese | WPRIM | ID: wpr-842279
Responsible library: WPRO
ABSTRACT
Bentysrepinine (Y101), a derivative of repensine, is a novel di-peptide structure isolated from Dichondra repens. In vitro and in vivo tests exhibited that bentysrepinine markedly inhibited DNA-HBV and cccDNA activities. The binding mode of Y101 and repensine with DNA polymerase was driven by hydrophobic interactions. This might provide novel recognition of inhibitory effect of Y101 against HBV, though its inhibition mechanism needs to be validated by bio-assay at cellular level and of polymerase activity. Preliminary docking study suggested that Y101 might be able to inhibit HIV inverse transcriptase, also have the potential to interact with DNA polymerase and HCV NS5B polymerase.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Herbal Medicines Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Herbal Medicines Year: 2015 Type: Article