A New Sesquiterpenoid Glycoside from Rhizomes of Atractylodes lancea / 中草药·英文版
Chinese Herbal Medicines
;
(4): 371-374, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-842310
ABSTRACT
Objective:
To study the water-soluble chemical constituents from the rhizomes of Atratylodes lancea.Methods:
Two sesquiterpenoid glycosides were purified by column chromatography and their structures were determined by spectroscopic analysis. They were also evaluated for anti-inflammatory activity by determining the inhibitory activity on LPS-induced NO and PGE2 generation in RAW 264.7 cell lines.Results:
Compound 1 was a new sesquiterpenoid glycoside, named as (1S,4S,5R,7R,10S)-4,11,14-trihydroxy-guai-3-one-11-O-β-D-glucopyranoside, but exhibited no appreciable activity. Compound 2 was atractyloside A and showed weak activity.Conclusion:
The hydroxyl group at C-10 of guaiol-type glycoside could be important for anti-inflammatory activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Herbal Medicines
Year:
2015
Type:
Article
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