Antihyperglycemic Effect of Various Fractions from Residues of Blumea balsamifera / 中草药·英文版

ABSTRACT

Objective: To evaluate the antihyperglycemic activities of various fractions from the residues of Blumea balsamifera (BB), and to properly utilize the waste resource. Methods: The antihyperglycemic activities were evaluated by the suppression on serum glucose level in vivo and α-glucosidase inhibition assay in vitro. The high-, mid-, and low-dose (1, 0.5, and 0.25 g/kg of the herb) fractions were ig given to mice for 8 d. The serum glucose was monitored at 1 and 12 h after feeding. Results: The fasting and postprandial serum glucose levels of mice treated with high-dose petroleum ether fraction, ethyl acetate fraction, butyl alcohol fraction, methanol fraction, and water extract from BB were 4.45, 4.39, 4.43, 4.15, 3.74 mmol/L and 6.98, 6.23, 6.45, 6.26, 5.88 mmol/L, respectively, while those in vehicle control group were 5.63 and 7.50 mmol/L. There are four different inhibiting manners by the results of α-glucosidase inhibition assay. Conclusion: The residues of BB have anti-diabetes activities after steam distillation. © 2014 Tianjin Press of Chinese Herbal Medicines.