Saponins from Roots of Panax notoginseng / 中草药·英文版

ABSTRACT

Objective: To study the chemical constituents in the dried roots of Panax notoginseng. Methods: The constituents were isolated and purified with chromatographic methods. Their structures were elucidated by spectroscopic methods (1D, 2D NMR, UV, IR, [α]D, and HRESI-TOF-MS) and chemical analyses. Results: Twenty saponins including 20(S)-ginsenoside Rh1 (1), 6-O-β-D-(6'-acetyl)-glucopyranosyl-24-ene-dammar-3β, 6α,12β,20S-tetraol (2), ginseno- side Rf (3), notoginsenoside R2 (4), ginsenoside Rg2 (5), ginsenoside Rg1 (6), notoginsenoside Rt (7), koryoginsenoside R1 (8), 6-O-(β-D-glucopyranosyl)-20-O-(β-D-xylopyranosyl)-3β,6α,12β,20(S)-tetrahydroxy-dammar-24-ene (9), pseudoginsenoside Rt3 (10), notoginsenoside R1 (11), ginsenoside Re (12), notoginsenoside N (13), ginsenoside F1 (14), ginsenoside U (15), ginsenoside Rk3 (16), 3β,12β-dihydroxydammar-(E)-20(22),24-diene-6-O-β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranoside (17), ginsenoside Rh4 (18), pseudoginsenoside Rt5 (19), and vinaginsenoside R22 (20) were obtained. Conclusion: Compounds 2, 19, and 20 are isolated from this species for the first time. The 1H-NMR data of compound 19 and 1H-NMR and l3C-NMR data of compound 20 are first reported. Meanwhile, the NMR data of β-D-xylopyranosyl group in compound 9 is corrected. © 2014 Tianjin Press of Chinese Herbal Medicines.