Study on the prognosis of intravenous thrombolysis in patients with ischemic stroke by thyroid-related hormones and antibodies / 上海交通大学学报（医学版）

ABSTRACT

Objective: To explore the association between thyroid-related hormones and antibodies and the prognosis of ischemic stroke pa-tients treated with intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA). Methods ¡¤ A total of 213 consecutive pa-tients with ischemic stroke who underwent rt-PA intravenous thrombolysis in the Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, were retrospectively included from May 2012 to August 2018. Thyroid-related hormones and antibodies were tested on admission, and assessment of intracranial hemorrhage (ICH) was conducted 24 hours after thrombolysis. Func-tional outcomes were assessed by modified Rankin Scale (mRS) after 3 months of follow-up. The relationship between thyroid-related hormones and antibodies and the prognosis (including functional outcome and ICH) was analyzed by logistic regression analysis. Results ¡¤ In univariate regression analysis, free triiodothyronine (fT3), total triiodothyronine, (tT3) and total thyroxine (tT4) levels were associated with poor functional prognosis (P=0.000, P=0.028, P=0.000) and fT3, and free thyroxine (fT4) levels were associated with ICH (P=0.008, P=0.014). However, after adjustment for other variables, low fT3 levels were independently associated with poor prognosis (OR=0.35, 95%CI 0.138-0.890, P=0.027), and both fT3 and fT4 levels had nothing to do with ICH. In addition, fT3 was negatively correlated with stroke severity (r=-0.291, P=0.000). Con-clusion ¡¤ Low fT3 levels are associated with stroke severity and functional outcome.