Value of contrast-enhanced ultrasound quantitative analysis in differential diagnosis of benign and malignant breast intraductal lesions / 上海交通大学学报（医学版）

ABSTRACT

Objective: To evaluate the value of contrast-enhanced ultrasound quantitative analysis in the differential diagnosis of benign and malignant breast intraductal lesions. Methods ¡¤ A retrospective analysis was made on the characteristics of conventional ultrasound and the time-intensity curve (TIC) of contrast-enhanced ultrasound (CEUS) of 71 breast intraductal lesions in 63 patients, which were surgically resected and pathologically confirmed in Shanghai Tenth People’s Hospital from January 2016 to December 2018. The parameters of CEUS perfusion in the lesion area were obtained. Independent sample t test was used to analyze the differences of quantitative parameters between benign and ma-lignant lesions. The receiver operating characteristic (ROC) curve was used to evaluate the value of conventional ultrasound, quantitative analysis of CEUS and their combination for the differential diagnosis of benign and malignant intraductal lesions of breast. Results ¡¤ There were 42 benign lesions and 29 malignant lesions. Among the quantitative parameters of CEUS, time to peak (t=2.072, P=0.042), peak intensity (t=-2.629, P=0.011), rise slope rate (t=3.015, P=0.004) and the area under the curve (AUC) (t=3.308, P=0.001) were statistically significant. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and area under the ROC curve of conventional ultrasound were 31.03%, 90.48%, 66.20%, 69.20%, 65.50% and 0.608. Those of quantitative analysis of CEUS were 75.86%, 71.43%, 73.24%, 64.70%, 81.10% and 0.776. And those of their combination were 86.21%, 97.62%, 92.96%, 96.15%, 91.11% and 0.943. Conclusion ¡¤ Conventional ultrasound is of limited value in the diagnosis of breast intraductal lesions, and quantitative analysis of CEUS is of great significance in differentiating benign from malignant breast intraductal lesions. The combination of conventional ultrasound and quantitative analysis of CEUS can significantly im-prove the diagnostic value.