Expression and clinical significance of long-chain non-coding RNA lincRNA-BBOX1-2 in gastric cancer / 上海交通大学学报（医学版）

ABSTRACT

Objective: To evaluate the expression of long-chain non-coding RNA (lncRNA) lincRNA-BBOX1-2 in gastric cancer tissues and the value of diagnosis and prognosis of gastric cancer. Methods:The expression of lincRNA-BBOX1-2 was detected by real-time quantitative PCR in 45 cases of gastric cancer and adjacent normal tissues. The correlations of lincRNA-BBOX1-2 expression with clinic-pathological features and clinical prognosis were analyzed. Results: The higher expression of lincRNA-BBOX1-2 was observed in the gastric cancer tissues (3.291±0.274 vs 1.125±0.075, P=0.000) as compared with the adjacent normal tissues. Up-regulation of lincRNA-BBOX1-2 was associated with positive lymph node metastasis (P=0.005, r=0.172) and advanced clinical stage (P=0.013, r=0.137). Receiver operating characteristic curve analysis showed that the area under the curve (AUC) value was 0.916 (95%CI 0.859-0.972) for lincRNA-BBOX1-2 in predicting the occurrence of gastric cancer, and 0.720 (95%CI 0.565-0.875) for lincRNA-BBOX1-2 in predicting the lymph node metastasis. Conclusion:The up-regulation of lincRNA-BBOX1-2 expression in gastric cancer tissues is associated with the clinic-pathological features of gastric cancer. lincRNA-BBOX1-2 may be used as a potential diagnostic biomarker in patients with gastric cancer.