Research progress on role of miR-195 in schizophrenia / 上海交通大学学报（医学版）

ABSTRACT

Schizophrenia is a serious mental health illness with unknown etiology, high prevalence, high morbidity and heavy social burden. Some RNAs with regulatory functions may be involved in pathogenesis of many complex diseases, including schizophrenia. miRNAs are non-coding RNAs that negatively regulate gene expression. Differential miRNA expression has been found in the brain and peripheral blood of patients with schizophrenia. miR-195 is an important member of the miR-15/16/195/497 family. Previous studies have implicated that miR-195 may be involved in the pathogenesis of schizophrenia due to its differential expression. This review aimed to clarify the function of miR-195 and summarized the recent researches of miR-195 in schizophrenia.