Value of hypoxia-inducible factor 1α in diagnosis and prognosis of acute decompensated chronic heart failure / 上海交通大学学报（医学版）

ABSTRACT

Objective: To investigate the value of hypoxia-inducible factor 1α (HIF-1α) in diagnosis and prognosis of acute decompensated chronic heart failure (CHF). Methods: 32 patients with acute decompensated CHF (Group A), 33 patients with stable CHF (Group B) and 30 controls (Group C) were included. HIF-1α, B-type natriuretic peptide (BNP) and other biochemical indicators in blood were detected. Length of stay and readmission frequency within 3 months of Group A were recorded. Correlations between HIF-1α and other indicators were analyzed. ROC curves of HIF-1α and BNP were developed to compare their diagnostic values. Results: The HIF-1α and BNP levels of Group A were both significantly higher than those of Group B and Group C (P0.05). Conclusion: HIF-1α has a certain value in diagnosis and prognosis of acute decompensated CHF.