Comparison of ex vivo lung perfusion with cold storage in rat donor lung preservation / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
;
(12): 151-154, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-843772
ABSTRACT
Objective:
To establish stable rat ex vivo lung perfusion (EVLP) model and compare the effect of preservation between EVLP group and cold storage group.Methods:
Eight SD rats were reconditioned with EVLP for 4 h and 8 SD rats were under 3-h cold storage and 1-h EVLP. The biological index, wet-to-dry weight ratio and concentration of Evans blue were analyzed between two groups.Results:
Wet-to-dry weight ratio of lung tissue in EVLP group was significantly lower (5.08±0.88 vs 6.09±0.48, P=0.012); Oxygenation index in EVLP group was significantly higher [(337.9±35.5) mmHg vs (300.5±21.6) mmHg, P=0.023]; Concentration of Evans blue in EVLP group was significantly lower [(36.5±20.3) μg/mL vs (65.0±29.9) μg/mL, P=0.043].Conclusion:
EVLP as an alternative to traditional cold storage technique can effectively alleviate the lung damage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Shanghai Jiaotong University(Medical Science)
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS