Preliminary screening and study of novel flavonoid monoacylglycerol lipase inhibitors / 上海交通大学学报（医学版）

ABSTRACT

Objective: To discover and develop novel monoacylglycerol lipase (MAGL) inhibitors. Methods: Computational screening, rational structure analysis and biological assessment was used. Results: A series of natural flavonoid MAGL inhibitors were identified. Compound 9 (quercetin) presented the highest activity with an IC50 value of 36 μmol/L. Conclusion: Several natural flavonoid MAGL inhibitors were identified, which are expected to bring novel hits for discovery of MAGL inhibitors.