Association between depression and metabolomic biomarkers of patients with amyotrophic lateral sclerosis / 西安交通大学学报(医学版)

ABSTRACT

Objective: To investigate the association between the incidence of depression and the levels of metabolomic indexes of patients with amyotrophic lateral sclerosis (ALS). Methods: We recruited 206 ALS patients admitted to The First Affiliated Hospital of Xi'an Jiaotong University between November 2013 and November 2018 using Hamilton Rating Scale for Depression (HRSD-17) to evaluate the degree of depression. Meanwhile, we also collected body mass index (BMI), creatinine, uric acid, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other metabolic indexes of these patients. Correlation analysis and regression analysis were preformed between depression score and the metabolic indexes. Results: Univariate analysis showed that the proportion of women was higher in the depression group than in the non-depression group (55.2% vs. 35.4%, P=0.005). In the depression group, BMI (21.36±2.70 vs. 22.86±3.16, P=0.001), creatinine (47.04±10.26 vs. 52.18±10.70, P=0.001), uric acid (279.39±70.30 vs. 308.49±81.37, P=0.008), and triglyceride (4.12±0.76 vs. 4.38±0.83, P=0.024) were lower than those in the non-depression group. Spearman rank correlation analysis showed that depression score was negatively correlated with BMI (rs=-0.172, P=0.013), creatinine (rs=-0.241, P<0.001), uric acid (rs=-0.224, P=0.004), and total cholesterol (rs=-0.201, P=0.002). Multivariate Logistic regression analysis showed that female [OR=2.585, CI (1.400, 4.774), P=0.002], BMI [OR=0.853, CI (0.769, 0.947), P=0.003] and triglyceride [OR=0.669, CI (0.449, 0.999), P=0.049] were negatively correlated with depression in ALS patients. Further analysis showed that when BMI was low, the proportion of patients with depression increased significantly. Conclusion: Factors such as low BMI, low triglyceride and female may increase the risk of depression in ALS patients. More attention should be paid to these factors in clinical work and reasonable intervention should be given timely.