Correlation between the level of serum uric acid and renal functions in type 2 diabetic patients / 西安交通大学学报(医学版)

ABSTRACT

Objective: To investigate the prevalence of hyperuricemia in type 2 diabetic patients and explore the correlation between the level of serum uric acid and kidney functions in type 2 diabetic patients. Methods: The demographic and clinical data of type 2 diabetic patients treated in The First Affiliated Hospital of Xi'an Jiaotong University from January 2018 to December 2018 were collected and retrospectively analyzed. Measurement data were described by mean±SD, and enumeration data were presented by percentage. Pearson correlation and Logistic regression were performed to evaluate the correlation between the level of serum uric acid and kidney functions. Results: Of all the 808 type 2 diabetic patients aged 54.81±14.26 years, 525 (64.98%) were males and 283 (35.02%) were females. The prevalence of hyperuricemia in type 2 diabetic patients was 16.46%. Pearson correlation analysis showed that the level of serum uric acid was negatively associated with estimated glomerular filtration rate (eGFR) (r=-0.181, P368 μmol/L) quartile group was 1.55 (95% CI 0.71-3.37), 4.03 (95% CI 1.89-8.49) and 7.09 (95% CI 3.37-14.89), respectively. Conclusion: The level of serum uric acid is negatively associated with eGFR. High level of serum uric acid is associated with increased prevalence of CKD.