Effects of glandular differentiation to the prognosis of patients with bladder urothelial carcinoma in PT1 / 西安交通大学学报(医学版)

ABSTRACT

Objective: To explore the effects of glandular differentiation (GD) on the prognosis of bladder urothelial carcinoma (BUC) in pT1. Methods: We retrospectively analyzed the clinical and pathological data of 248 BUC patients in pT1, 82 of them with glandular differentiation as UCGD group and the other 166 patients with pure BUC but without histological variants as control group. Results: The prognosis was significantly worse in UCGD group than in the control group (P=0.007). In univariate analysis, lymphovascular invasion (HR 1.416,95% CI 1.120-2.254, P=0.013) and glandular differentiation (HR 1.367, 95% CI 1.115-1.853, P=0.038) were significantly related to the prognosis of the patients. In multivariate analysis, glandular differentiation (HR 1.462, 95% CI 1.138-2.393, P=0.007) and lymphovascular invasion (HR 1.348, 95% CI 1.052-1.944, P=0.022) were independent factors related to the prognosis of PT1 BUC patients. Conclusion: The prognosis of PT1 UCGD patients is significantly worse than that of pure PT1 BUC patients. Therefore, UCGD patients should be regularly followed up and reviewed after the operation and should receive radical cystectomy if necessary.