Recurrence of Helicobacter pylori infection and its influencing factors / 西安交通大学学报(医学版)

ABSTRACT

Objective: The recurrence of Helicobacter pylori (Hp) infection directly affects the prevention and treatment of Hp-related diseases, and the recurrence rate varies greatly in different countries and regions. We conducted this study to determine the recurrence rate of Hp infection and its influencing factors in Xi'an. Methods: We enrolled 497 patients receiving successful Hp eradication in the follow-up study. One year after the eradication therapy, 13C-urea breath test (UBT) was performed to calculate its recurrence rate. Meanwhile, a questionnaire survey was performed to analyze the factors affecting the recurrence. Results: ① A total of 422 patients completed 13C-UBT. Among them, 12 patients had recurrence of Hp infection, with an annual recurrence rate of 2.84% (95% CI 1.25%-4.42%). ② Univariate analysis showed that the type of disease, income, hygienic conditions of restaurants, contact with individuals having Hp infection and hospitalization were related to Hp recurrence (P<0.05). ③ Multivariate analysis revealed that low income (OR=3.06, 95% CI 1.24-12.76, P=0.028), poor hygienic conditions of restaurants (OR=9.16, 95% CI 2.65-32.64, P=0.039), contact with individuals having Hp infection (OR=4.27, 95% CI 1.96-13.92, P=0.034) were independent risk factors of Hp recurrence. Conclusion: The recurrence rate of Hp infection in Xi'an is low. Low income, poor hygienic conditions of restaurants and contact with individuals infected with Hp are risk factors for the recurrence.