Change in plasma selenium level of patients with chronic kidney disease at different stages and its correlation with clinical indicators / 西安交通大学学报(医学版)

ABSTRACT

Objective: To explore the severity of selenium (Se) deficiency in different stages of chronic kidney disease (CKD) and its relationship between Se content and clinical indicators and other elements. Methods: We detected the clinical indicators and element contents including Se, iron, copper, calcium, potassium and phosphorus of 107 subjects who were 23 healthy controls, 10 of CKD3 stage, 11 of CKD4 stage, 45 of CKD5 stage, 6 on peritoneal dialysis, 12 on hemodialysis. Results: With the progression of CKD, plasma Se level in the patents got lower, especially in ESRD and PD groups. Plasma Se level had significantly positive correlation with albumin, total cholesterol and triglyceride, but negative correlation with parathyroid hormone, blood urea nitrogen and serum creatinine. Plasma Se level had significantly positive correlation with calcium level. Conclusion: Se deficiency does exist in CKD patients, and it correlates with CKD severity and other clinical indicators. Further studies are needed to clarify the real extent of Se deficiency and carry out Se supplementation in patients with kidney disease.