Treatment effects of Wenshen-huatan method in patients with stable COPD / 西安交通大学学报(医学版)

ABSTRACT

Objective: To investigate the effects of Wenshen-huatan method in patients with stable chronic obstructive pulmonary disease (COPD). Methods: Totally 146 patients with stable COPD admitted to the First Affiliated Hospital of Guangzhou Medical University from March 2016 to December 2017 were randomly divided into observation group and control group, with 73 in each group. The control group received routine treatment, while the observation group received Wenshen-huatan method based on the control group. The clinical efficacy and adverse reactions were compared between the two groups. Pulmonary function indexes, blood gas analysis indexes, modified medical British Research Council (mMRC) scores, 6-minute walking distance (6 WMD), serum nuclear factor-κB (NF-κB), soluble intercellular adhesion factor-1(sICAM-1), transforming growth factor-β1 (TGF-β1), and chemokine CC-motif ligand 18 (CCL-18) were measured before and after treatment. Results: The total effectiveness rate in the observation group was 93.15%, which was significantly higher than 79.45% in the control group (P<0.05). After treatment, the mMRC score and the TCM syndrome score were significantly lower in the observation group than those in the control group; the 6 MWD was significantly higher than that in the control group (P<0.05). The lung function index [forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1% pred, FEV1/FVC, peak expiratory flow rate (PEFR)], partial pressure of carbon dioxide (PaO2), and arterial oxygen pressure(SaO2) in the observation group were significantly higher than those in the control group; PaCO2 was significantly lower than the control group (P<0.05). The serum NF-κB, sICAM-1,TGF-β1, and CCL-18 in the two groups were significantly decreased, and the observation group had significantly lower levels than the control group (P<0.05). Conclusion: Wenshen-huatan method is effective for the treatment of stable COPD in that it can improve clinical symptoms, respiratory muscle fatigue and lung function, and can down-regulate the peripheral blood levels.